The College of Education for Pure Sciences at the University of Basrah organized a scientific lecture on (Using cyclodextrin to improve the solubility of low soluble drugs)
The lecture presented by the researcher (Tawfiq Kazem Mahdi) included
The use of cyclodextrin and its derivatives to improve the solubility of low soluble drugs such as emodin, lidocaine, nateglinide, and phloritin by forming implicit complexes, where the solubility in water was improved to a very large degree compared to the free drug.
The purpose of the lecture
(Increasing the solubility of drugs that are less soluble in water)
Cyclodextrin increases the aqueous solubility of a large number of substances that are insoluble in water by forming implicit complexes with it due to its distinctive structure.
Most of the pharmaceutical substances have a low solubility in water to be absorbed through the cell membrane, so cyclodextrin was used in the pharmaceutical industry to change many of its physical and chemical properties, the most important of which is increasing solubility and chemical stability.
Cyclodextrin has a distinctive ability to increase drug delivery through biological membranes, so cyclodextrin acts as a true carrier by keeping the drug molecules hydrophilic in solution and delivering them to the surface of the biological membrane such as the skin, mucous membrane and cornea of ​​the eye, where they diffuse through the membrane easily

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