The College of Education for Pure Sciences, Department of Life Sciences, discussed a doctoral thesis on the study of some physiological and immunological evidence in patients with rheumatoid arthritis.
The thesis managed by the researcher (Munira Mansour Adlan) included the current study on women suffering from rheumatoid arthritis in Basra Governorate - Iraq. Anti-citrulline protein (ACPA), rheumatoid factor (RF-IgM), C-reactive protein (CRP), vascular endothelial growth factor (VEGF), monocyte chemoattractant protein (MCP-1), low-density oxidative lipoprotein (Ox-LDL) ) and paroxonase enzyme (PON-1), the study included the collection of (90) blood serum samples from women only, and distributed to (60) serum samples for women with rheumatoid arthritis and (30) serum samples from non-infected (healthy) women. The disease was divided into three categories according to age (20-35 years, 35-50 years and 50-65 years), and the severity of the disease was divided according to the disease activity scale specified by the specialist doctor into (severe, moderate and mild infection) and the time period of the disease It was also divided into two periods (the first period of a month - 3 years and the third vessels from 3-20 years old) (noting that the number of patient samples and the number of healthy samples that were used in the immunological tests were (56) and (24) respectively) and samples were collected from the Basra General Hospital Consultation, Al Zubair General Hospital and some private clinics.
     The results of the current study showed a significant increase in the concentration of all studied biomarkers in samples of women patients who suffer from rheumatoid arthritis compared to healthy controls at a probability level of P<0.05 with the T-test, in addition to, significant differences in the concentration of all specific biomarkers. between the three age groups and at the probability level of P<0.05 for the least significant difference (LSD) test with the exception of the biomarker Ox-LDL, as no significant difference was recorded in its concentration among the three age groups. The studied vitality except for the two biomarkers MCP-1 and PON-1. As for the effect of the time period of the disease on the concentration of biomarkers, significant differences were found in the concentration of the biomarkers ACPA, VEGF, MCP-1 and Ox-LDL, according to the two disease periods, while we did not get significant differences in the concentration of adiponectin, IL-6 and RF-IgM and CRP and PON-1 between the two disease periods.
Thesis objective
Evaluating the concentrations of some vital signs in patients and studying the physiological and immunological relationship between these vital signs and rheumatoid arthritis disease. Finding the relationship between age, disease severity and disease period with the concentration of these vital signs in rheumatoid arthritis patients.
 Study the relationship between liver function (measurement of enzymes Alanine aminotransferase (ALT), Aspartate aminotransferase (AST) and Alkaline phosphatase (ALP)) and kidney function (measurement of creatinine, urea and total protein) and Lipid profile (triglycerides (TC) ) and cholesterol (cholestrol) with rheumatoid arthritis disease.
The possibility of adopting some vital signs as diagnostic predictors of other diseases. The use of some biomarkers as diagnostic indicators for rheumatoid arthritis.
Thesis concluded
Significant correlation of the studied biomarkers with the pathological inflammatory status of the serum of women suffering from rheumatoid arthritis as a result of the high concentrations of all biomarkers.
Adopting these indicators as diagnostic criteria for patients with rheumatoid arthritis.
These criteria may help in early detection of the disease and as predictive markers of disease progression, and can be adopted to predict the therapeutic response to rheumatic disease.
The increase in age caused a significant effect on the concentration of biomarkers, which increases the severity of the disease.
The biomarkers under study (with the exception of MCP-1 and PON-1) can be adopted to determine the severity of the disease, due to a significant increase in the concentrations of most of these indicators in severe disease infection compared to moderate and mild infection.
These biomarkers can be adopted as dangerous predictors of the occurrence of some diseases such as cardiovascular diseases and others in patients with rheumatoid arthritis.
Rheumatoid arthritis in the current study had no significant effect on liver and kidney function.