The Department of Biology at the College of Education for Pure Sciences at the University of Basra organized a scientific lecture entitled the effect of carcinogenic compounds on physiological and histological parameters in experimental rats by a doctoral student (Shatha Qasim Kazim). The study included that cancer is a group of diseases that involve abnormal growth of cells With possible invasion or spread of other parts of the body.
Carcinogens may increase the risk of cancer by altering cellular metabolism or directly damaging the DNA in cells, which interferes with biological processes, and stimulates uncontrolled malignancy, leading to the formation of tumors.
Carcinogens are any chemical substance, nanoparticles, radionuclides, or radiation that promotes carcinogenesis, and this may be due to the ability to damage the genome or to disrupt cellular metabolic processes.
Nanoparticles that are carcinogenic are NiO NPS. Cobalt dioxide, carbon dioxide, titanium dioxide, TiO2 and zinc oxide nanoparticles. ZnO nanoparticles can cause cytotoxic effects and may cause cancer
Objectives of the study:
1- Study of the effect of ZnO NPS on liver enzymes (AST, ALT, ALP).
2- The effect of ZnO NPS on kidney function
(Creatinine and urea)
3- Study of the effect of ZnO NPS on the antioxidant enzyme (catalase and superoxide superoxide dismutase).
4- Histological study on organs (liver, kidneys, lung) - the effect of ZnO NPS on the molecular level of inflammation and apoptosis by following gene expression of some inflammatory and apoptotic genes (MMP12, Caspase-8 and Caspase-9).
Applications of ZnO nanoparticles