The College of Education for Pure Sciences, Department of Life Sciences, discussed a doctoral thesis on a physiological, immunological and molecular study in women with thyroid disorder.
The thesis presented by the researcher (Duha Talib Hamid Al-Tai) included the present study designed to study the effect of thyroid dysfunction on physiological and immunological parameters in women in Maysan Governorate - Iraq. It also addressed the effect of mutations on women who suffer from thyroid disorders (hypothyroidism and hyperthyroidism).
This study was conducted in Maysan Governorate during the period from November 2019 to May 2020, and included (150) women, who were divided into (50) as a control group and (100) as groups of patients, (50 hypothyroidism and 50 hyperthyroidism). . Their ages ranged between (15-64) years, and they attended Al-Sadr Teaching Hospital and the Diabetes and Endocrinology Center in Maysan. The women were divided into five groups, and each group was divided into five age groups as follows: the first group (15-24) years, the second group (25-34) years, the third group (35-44) years, the fourth group ( The group is 45-54 and the fifth group is (55-64) years old, and each group consists of (12), (39), (39), (42) and (18) women, respectively.
The results of thyroid hormone analysis showed a significant decrease (P≤0.05) in the levels of thyroid hormones FT3, FT4, T3 and T4 in hypothyroid patients, while a significant increase was observed in hyperthyroid patients. On the other hand, there is a significant increase in the level of TSH in hypothyroid patients, while a significant decrease in hyperthyroid patients in all age groups compared with the control group.
Five new mutations were diagnosed in the current study in the tenth coding region of the TSHR gene in one patient with hyperthyroidism compared to the control group On the other hand, the current study revealed 35 new mutations in the tenth coding region of the Tg gene, (23) mutations in seven patients with hypothyroidism and (12) a mutation in five patients with hyperthyroidism. In addition, the current study did not record any mutation in the THRB gene in both patients with hypothyroidism and hyperthyroidism.
The aim of the thesis
Determining the relationship of thyroid disorder to age and body weight
Study of the effect of thyroid disorder on physiological parameters
 Investigating the relationship of thyroid disorder with immunological criteria
 Determining the relationship of thyroid gene mutations to thyroid disorder