The College of Education for Pure Sciences in the Department of Chemistry at the University of Basra discussed the preparation and study of the biological activity of some new thiazolidine derivatives derived from penicillamine.
The thesis presented by the researcher (Haider Abdul Salam Omran) included the preparation and diagnosis of new compounds for thiazolidine carbohydrazide, and the study of their biological activity. The compounds TH.x1-TH.x5 were prepared from the reaction of various aromatic aldehydes with D-Penicillamine and then the reaction of the prepared compounds with Acetic anhydride. To prepare TH1-TH5 compounds for the purpose of protecting the amine group, then TH1-TH5 compounds were reacted with some hydrazide compounds to obtain thiazolidine carbohydrazide.
Aim of the study
Preparation of some new thiazolidine carbohydrazide compounds derived from 3-acetyl-5,5-dimethyl-2-phenylthiazolidine-4-carboxylicacid with hydrazide compounds and their identification by infrared spectroscopy, nuclear magnetic resonance spectroscopy (NMR) and NMR spectroscopy Mass spectroscopy.
Studying the biological activity of the prepared compounds as anti-bacterials.
deduce the message
Through preparation and study, the following can be concluded:
The study showed the ease of preparation of thiazolidine derivatives from different aromatic aldehydes with penicillamine, the ease of their purification and identification by spectroscopic techniques, and the presence of stereoisomers that are difficult to separate because they contain chiral atoms.
The study showed that the method of preparing thiazolidine compounds using Isoniazid is a difficult method and its yield is low, while the result was good when the thiazolidine compounds interacted with benzohydrazide.
The study showed that the prepared compounds (thiazolidine and thiazolidine amide) have biological activity against the two types of bacteria S.aureus and E.coli, and the compound H.A5 is the most effective.
Recommended letter
Preparation of new thiazolidine derivatives from aldehydes and ketones and their comparison with the prepared compounds. Preparation of thiazolidine amide compounds using new pairing reagents that are characterized by ease of disposal and purification.
And the possibility of separating the stereoisomers of the prepared compounds and studying the biological activity of each isomer and knowing which isomers are more effective than the other.