The College of Education for Pure Sciences at the University of Basra discussed a doctoral thesis on the preparation and diagnosis of some new thiazolidine derivatives and the study of their effectiveness against bacteria and as antioxidants
The thesis presented by the researcher (Mahdi Odeh Muhammad) included the preparation of two types of heterocyclic pentacyclic compounds as derivatives of thiazolidine, which are as follows:
The first type: Preparation of new compounds of thiazolidine-4-carboxylic acid (A13-A1) resulting from condensation between penicillamine and some substituted aldehydes. 2,2-diphenyl-1-picrylhydrazyl (2,2-diphenyl-1-picrylhydrazyl (DPPH) The results showed that the reaction of the prepared compounds (A13-A1) with DPPH depends on time and concentration, as there is an increase in the activity of scavenging free radicals (radical scavenging), as it was noted that the activity of the studied thiazolidine-4-carboxylic acid derivatives depends on the substituted groups on the substituted vinyl ring in position No. ), due to the presence of three compensated hydroxyl groups on the phenyl ring capable of donating a proton to the free radical, and it was found that the compound A1 has weak activity due to the lack of a donor proton.
The second type: Preparation and characterization of thiazolidine-4-carboxylicamide compounds, and evaluation of their biological activity. The compound 3-acetyl-5,5-dimethyl-2-phenylthiazolidine-4-carboxylic acid (At) was prepared from the reaction of 2-phenyl-5, 5-Dimethyl thiazolidine-4-carboxylic acid (A1) with acetic acid anhydride, which represents a protective reaction for the amine group in the thiazolidine ring, then the compound (At) was reacted with some aromatic amines to obtain thiazolidine-4-carboxylicamide (b13). -b1), and some preliminary tests were conducted to test the effectiveness of the prepared compounds as anti-growth of two types of microorganisms, one of which is positive towards gram staining and the other is negative towards gram stain.
The aim of the thesis
Synthesis of some new thiazolidine-4-carboxylic acid derivatives derived from different penicillamine and aldehydes and their identification by infrared spectra, nuclear magnetic resonance spectra and mass spectra.
Study of some compounds prepared as antioxidants.
Preparation of some new thiazolidine amide derivatives derived from 3-acetyl-2-phenylthiazolidine-4-carboxylic acid and their identification by infrared spectra, nuclear magnetic resonance spectra and mass spectra.
Study of some compounds prepared as antibacterials.
Thesis concluded
Ease of preparation of thiazolidine derivatives from aldehydes with penicillamine and ease of their purification and identification by spectroscopic techniques
It was characterized by the presence of difficult-to-separate stereoisomers because they contain chiral atoms.
One of the disadvantages of the method of preparing thiazolidine amide compounds using dicyclohexylcarbodiimide (DCC) is
The difficulty of getting rid of the by-product (DCU), and the lack of its outcome, as well as the need for a long time.
A number of the prepared compounds, thiazolidine derivatives (A13-A1) possess antioxidant activity. A number of the prepared compounds, thiazolidine amide (b13-b1) have biological activity.