A master's thesis at the University of Basrah discussing (preparation of some 4-thiazolidinone derivatives using ultrasound and studying their biological effectiveness against esophageal cancer)

The College of Education for Pure Sciences, Department of Chemistry, discussed a master's thesis on (preparation of some 4-thiazolidinone derivatives using ultrasound).
ultrasound and studying its biological efficacy against esophageal cancer)
The thesis presented by the researcher (Jinan Khudair Salem) included the preparation of ten 4-thiazolidinone derivatives: five
In two ways: the first is the traditional method (E1-E) and the other five are of type (5) (D1-D), including type (5).
The second method involved the use of ultrasound technology, and its effectiveness was evaluated (Reflux).
Biological antibody against esophageal cancer and study of the molecular docking process of two derivatives with efficacy
high biological. The compositions of all the prepared compounds were validated using spectra
Proton and carbon nuclear magnetic resonance, infrared spectroscopy, and mass spectrometry
fusion.
Message objectives
And the other five (D1-D-1) prepare ten 4-thiazolidinone derivatives: five of them are of type (5).
E1-E of type (5).
And the method (Reflux) -2 preparing 4-thiazolidinone derivatives: in two ways: the first is the traditional method.
The second included the use of ultrasound technology and a comparison between the two methods.
3- Evaluation of the biological activity of 4-thiazolidinone derivatives prepared against esophageal cancer.
High biological effectiveness. (E2-D-4 Study of the molecular docking process of two derivatives (5
MTT-5 derivatives inhibition tests were carried out experimentally on live cancer cells using the method
The preparation that gave theoretical inhibitory activity and evaluation of the results to determine the compounds as candidate drugs
As anti-cancer.
conclusions
Ultrasound technology was used in our research to prepare a number of 4 derivatives
thiazolidinone and compared with the usual heating method (retrodistillation) in order to obtain
Get better results in less time.
Using wave technology (E5-E1), (D5-D-2), a series of 4-thiazolidinone derivatives (1) were prepared.
ultrasound at room temperature.
3- The effectiveness of prepared 4-thiazolidinone derivatives in inhibiting the growth of esophageal cancer cells has been studied
The biological effectiveness of MTT was evaluated using a test method
- -4 The study showed that the 4-thiazolidinone ring linked to fenathryl-9-methylene and 4-
On esophageal cancer cells E and 2D nitrobenzylidene enhanced the significant toxic effect of the 5 derivatives.
(SKGT-Human) 4
They act on E and 2D-5 programmed cell death. The study showed that my derivative 4-thiazolidinone 5
A pathway that differentiates from inducing apoptosis in SKGT cells (esophageal cancer cells) 4
(Vero) Normal esophagus