The College of Education for Pure Sciences at the University of Basrah organized a scientific lecture on (Preparation of some 4-thiazolidinone derivatives using ultrasound -
Ultrasound and its biological efficacy against esophageal cancer)
The lecture presented by (Jinan Khudair Salem) included the preparation of ten 4-thiazolidinediones: five -
Some of them are of the type (D1-D5) and the other five are of the type (E1-E5) in two ways: the first is the traditional method
(Reflux) and the second method included the use of ultrasound technology and its effectiveness was evaluated
Biology against esophageal cancer and study of the process of molecular docking of two effective derivatives
High biological. The correctness of the compositions of all the prepared compounds was verified using spectra
Proton and carbon nuclear magnetic resonance, infrared spectroscopy, mass spectrometry, and degree
fusion.
Objectives of the lecture
Preparation of ten derivatives of 4 thiazolidinediones: five of them are of the type - (D1-D5) and the other five
Type (E1-E5).
Preparation of 4-thiazolidinedione derivatives: in two ways: the first is the traditional method - (Reflux) and the method
The second included the use of ultrasound technology and a comparison between the two methods.
Evaluation of the biological efficacy of 4-thiazolidinedione derivatives against esophageal cancer. –
And studying the process of molecular docking of two derivatives (E2-D5) with high biological activity.
And conducting inhibition tests in practice on live cancer cells using the MTT method of derivatives
The preparation that gave theoretical inhibitory activity and evaluated the results to identify the compounds as candidate drugs
As anti-cancer.
Conclusions:
Ultrasound technology was used in our research to prepare a number of 4-derivatives.
Thiazolidinone and its comparison with the usual heating method (reverse distillation) in order to obtain
Get the best results in the shortest possible time.